Evaluation of Antinociceptive and Antioxidant Activities of Mono and Bis-mannich Bases of Piperazine Derivatives

Neuropathic pain comprises a variety of painful conditions, including post amputation pain, painful neuropathies, post traumatic neuralgia, and others. So far, multiple factors responsible for development of neuropathic pain have been identified: metabolic diseases (e.g., diabetes), neuronal tissue injuries caused by toxicological factors or mechanical damage to the spinal cord, and others (Nickel et al. 2012; Woolf and Mannion 1999). Hence, pharmacotherapy used to relieve neuropathic pain comprises several pharmacological classes, of which anti-epileptic drugs (AEDs), antidepressant drugs, and local anesthetic agents play a pivotal role (Christoph et al. 2011; Davis 2007; Davis 2010; Gilron et al. 2009; Miranda et al. 2012). N-mannich bases and N-aryl piperazine derivatives were reported as anticonvulsant and antinociceptives respectively (Obnisca et al., 2010). In my earlier study, a series of N-mannich bases of piperazine derivatives were screened for anticonvulsant activity (Prasanthi., 2014). Pharmacological and clinical studies have documented the pathophysiological similarities in epilepsy and neuropathic pain models (Baruah et al., 2012). Therefore, the study was extended for antinociceptive and antioxidant activities for the previously reported derivatives using formalin induced nociceptive assay and DPPH free radical scavenging assay.